Clostridium Butyricum

About Clostridium butyricum


Clostridium butyricum is a strictly anaerobic spore-forming butyric acid-producing bacillus, it has been widely used as a probiotic in Asia (particularly in Japan, Korea, and China) for both the treatment and the prophylaxis of human gastrointestinal disease. It also has been demonstrated to have positive effect on improving livestock production performance, prevention of diarrhea, and effectively prevent and treatment of animal necrotic enteritis.

When orally administered, spores of Clostridium butyricum protect them from being killed by gastric acids, digestive enzymes, or bile, and then germinated in the upper small intestine, Vegetative growth began in the distal small intestine, and mainly grew and exert positive effect in the distal small intestine, cecum and colon.


Mode of action

lSCFAs constitute an important energy source for intestinal cells and have proliferative effects on enterocytes, maintain the integrity of the intestinal tissue.

lSCFAs have been noted to have immune-modulatory effects on colonic inflammation.

lLower intestinal pH controlling the overgrowth of pathogens and promote the proliferation of beneficial bacteria.

 Secret Bacteriocins such as butyricin, inhibited the growth of Clostridium perfringens and Salmonelladecrease the incidence of necrotic enteritis and other enteric diseases.

Prevents colonization of pathogens in the intestine by Competitive exclusion.

Produce hydrogen in the intestine and has a strong repairing effect on various internal organs, especially liver and spleen oxidative damage.


Effects of GBW Clostridium butyricum on weaned piglets performance

Weaning imposes tremendous stress on piglets, the period following weaning is characterized by a high incidence of intestinal disturbances with diarrhea and depression of growth performance in piglets.

A field experiment was conducted to investigate the effects of GBW Clostridium butyricum on the growth and health performance of weaned piglets.


Trail design and results:

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Note:Positive control: 300 ppm Chlortetracycline;

            Negative control: no probiotics and antibiotics supplementation;

            GBW Clostridium butyricum: 108 CFU/kg compound feed.


Effects of GBW Clostridium butyricum on finishing pigs performance

Supplemented with GBW Clostridium butyricum reduces FCR and increases daily weight gain of finishing pigs.


Trail design and results:

image.png

Note:Positive control: 300 ppm Chlortetracycline;

     Negative control: no probiotics and antibiotics supplementation;

     GBW Clostridium butyricum: 108 CFU/kg compound feed.


Effects of Clostridium butyricum on performance of Sows and Piglets

Sows and Piglets are the fundamental and future of pig farm respectively, the performance of Sows and 

Piglets are critical for a profitable pig production.


Trail design and results

A total of 22 pregnant sows were divided into two groups. The diet of Clostridium butyricum group was additionally supplemented with 200g Clostridium butyricum per ton compound feed, experiment start from 10 days prepartum to the wean of piglets.

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Effects of GBW Clostridium butyricum on Jejunum morphology and intestinal 

inflammation of LPS challenged broiler

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Lengthening of villi increase total luminal villus absorptive area and subsequently result in satisfactory digestive enzyme action and higher transport of nutrients at the villus surface. Moreover, the higher villus height to crypt depth ratio in the broilers supplements with GBW Clostridium butyricum resulted in a decreased turnover of the intestinal mucosa. A slower turnover rate of the intestinal epithelium results in a lower maintenance requirement, which can finally lead to a higher growth rate or growth efficiency of the animal.


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LPS is the main toxin factor of E. coli and salmonella, which cause livestock enteric disease. The results show that administrate Clostridium butyricum to LPS challenged broiler can down-regulate the mRNA expression of Pro-inflammatory factor, mitigate intestinal inflammation.


Note:Positive control: LPS challenge;

            Negative control: no probiotics and LPS challenge;

            GBW Clostridium butyricum: 108 CFU/kg compound feed.









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